Animal Models

Animal models services at PRISM provide cutting-edge solutions for preclinical research, offering accurate simulations of human diseases to enhance the development of new therapies

Customized Model Facility and Expertise

At PRISM CRO, we specialize in developing “customized disease models” tailored to your specific drug, device, or treatment options. Our expertise spans a wide range of species, including rats, mice, hamsters, rabbits, dogs, chickens, and monkeys. This versatility allows us to replicate various human disease conditions with high fidelity, ensuring that your research is relevant and impactful.

Benefits of Our Customized Models

Accurate Disease Simulation: Mimicking human disease conditions for reliable translational research.
Innovative Therapeutic Testing: Evaluating the efficacy and safety of novel drugs, devices, or therapies.
Flexible Experimental Designs: Adapting protocols to suit your research needs and objectives.
Rapid Turnaround: Efficient animal model development to accelerate your research timeline.

Partner with PRISM CRO to leverage our cutting-edge facilities and expertise in disease modeling. Let us help you advance your research and achieve your scientific goals with precision and confidence.

Why Choose Our Customized Models?

Tailored Solutions

We collaborate closely with clients to design animal models that meet your unique research objectives, providing a personalized approach to studying complex disease mechanisms

Expert Team

Our team of experienced researchers and veterinarians is skilled in advanced techniques and methodologies, ensuring high-quality model development and data collection.

Diverse Species Handling

With expertise across multiple species, we can select the most appropriate model organism for your study, enhancing the relevance of your findings.

Comprehensive Support

From initial consultation to data analysis, we offer end-to-end support, ensuring a seamless research experience and timely delivery of results.

Regulatory Compliance

We adhere to strict ethical and regulatory standards, ensuring that all our models and procedures are conducted with the highest care for animal welfare.

Our Disease Models

Diabetes Model

Our Diabetes Model is an advanced research tool designed to simulate and study the complexities of diabetes mellitus. This model accurately replicates essential biological processes, including insulin secretion and glucose metabolism, providing a comprehensive understanding of disease mechanisms.

At PRISM CRO, we have successfully developed an “Alloxan-induced diabetes model” in over 500 rats. This model is a robust platform for exploring therapeutic interventions, understanding pathophysiology, and testing potential treatments. By collaborating with us, clients gain access to cutting-edge research capabilities and a dedicated team committed to advancing diabetes research. Our models are tailored to meet specific research needs, ensuring high-quality, reliable data for your studies.

Liver Fibrosis

Liver fibrosis is a condition where healthy liver tissue is replaced by scar tissue resulting from chronic injury or damage. This scarring is caused by prolonged inflammation and the activation of hepatic stellate cells. Normally storing vitamin A, these cells transform into myofibroblast-like cells, producing excessive collagen and other extracellular matrix components.

At PRISM CRO, we have successfully developed a “Concanavalin-A induced liver fibrosis model” in 200 rats. This model is essential for understanding the mechanisms of liver fibrosis, enabling early detection and the development of effective intervention strategies to prevent disease progression. Our model supports research aimed at halting or reversing fibrosis, thereby preserving liver function and improving outcomes for individuals with liver disease. Partnering with us provides clients access to state-of-the-art research and a dedicated team focused on advancing liver health.

Oncology Models

Oncology models in rats are crucial for advancing our understanding of cancer biology and developing innovative treatments. These animal models closely mimic human cancer conditions, enabling researchers to study the intricate interactions between tumors and the host environment. By inducing tumors through methods such as chemical carcinogenesis or the implantation of tumor cells, we can observe tumor growth patterns, metastatic spread, and the molecular mechanisms underlying cancer progression. This detailed insight helps identify potential therapeutic targets and test novel drugs before they advance to clinical trials.

At PRISM CRO, we have successfully developed a “DMSO-injected breast cancer model”. This model is specifically designed to study breast cancer’s pathology and response to treatments, providing valuable insights into tumor biology and therapy efficacy.

In addition to breast cancer, our comprehensive suite of oncology models includes:

Lung Cancer Models: Utilizing carcinogens or tumor cell implantation to replicate lung cancer progression and metastasis, aiding in the evaluation of targeted therapies.
Colorectal Cancer Models: Induced through chemical agents or genetic modifications, these models help explore tumorigenesis and potential interventions.
Prostate Cancer Models: Developed to study tumor growth and response to hormonal therapies, these models are essential for advancing prostate cancer research.
Leukemia Models: Created by injecting leukemic cells, these animal models facilitate the investigation of blood cancers and the testing of new hematologic treatments.

Lung Inflammation

Lung inflammation, also known as pneumonitis or pneumopathy, refers to the body’s immune response to injury, infection, or irritants affecting lung tissue. It is characterized by activating immune cells and the releasing of inflammatory mediators, leading to swelling, increased blood vessel permeability, and immune cell recruitment to the affected area. This inflammatory process can impair lung function and, if unresolved, contribute to chronic lung diseases.

At PRISM CRO, we have developed a “lung inflammation model in rats by intratracheal instillation of lipopolysaccharide (LPS) from E. coli”. This model mimics the inflammatory response seen in human lung conditions, providing a valuable platform for studying the mechanisms of lung inflammation and testing potential anti-inflammatory therapies.

Our lung inflammation model offers insights into:

Acute and chronic inflammatory responses: Understanding the progression and resolution of inflammation in lung tissue.
Therapeutic interventions: Evaluating the efficacy of new drugs to reduce inflammation and improve lung function.
Pathophysiological mechanisms: Exploring how inflammation contributes to the development of chronic lung diseases.

Hypertension Model

Our stress-induced hypertension model is designed to replicate the physiological and behavioral responses observed in humans under stress. This model helps researchers understand how stress contributes to the development and exacerbation of hypertension (high blood pressure) and evaluates the effects of antidepressant medications on stress-related cardiovascular outcomes.

In this model, stress is typically induced in animal subjects through methods such as:

Chronic Restraint Stress: Animals are restrained for a specific duration daily, mimicking prolonged stress conditions.
Social Defeat Stress: Animals are exposed to a dominant aggressor, simulating social stress factors.
Environmental Stressors: Exposure to noise or unpredictable light cycles to induce stress.

These methods lead to increased blood pressure, replicating hypertensive conditions in humans. Researchers can then study cardiovascular responses, stress-related hormone levels, and behavioral changes.

At PRISM CRO, we have developed a robust stress-induced hypertension model in rats, providing valuable insights into the Pathophysiology of hypertension, Efficacy of antihypertensive and antidepressant drugs, Behavioral and physiological correlations exploring how stress and hypertension affect overall health.

Arthritis Model

The Adjuvant-Induced Arthritis (AIA) model in rats is a widely used experimental animal models for studying autoimmune arthritis, resembling aspects of human rheumatoid arthritis (RA). In this model, arthritis is induced by injecting an antigen, such as Collagen Induced Arthritis (CIA), emulsified in an adjuvant (like Freund’s complete adjuvant), typically via subcutaneous or intradermal routes. Upon injection, the rat’s immune system recognizes the collagen as a foreign antigen, triggering an inflammatory response. This leads to the infiltration of immune cells, particularly macrophages and T lymphocytes, into the synovial tissue of the joints. These immune cells release pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), contributing to synovial inflammation, cartilage degradation, and bone erosion, mirroring the pathology of RA in humans.

Collaborate with us to leverage advanced animal models and a dedicated team committed to advancing arthritis research and therapeutic development.

Cardiovascular models

Cardiovascular models in biomedical research encompass various experimental approaches to study the structure, function, and diseases of the heart and blood vessels. These animal models are essential for investigating cardiovascular physiology, pathophysiology, and the development of new therapeutic interventions.

At PRISM CRO, we utilize animal models, such as rodents and larger mammals, to mimic human cardiovascular conditions. These animal models can be induced through:

Genetic Manipulation: Creating transgenic or knockout animals to study specific genetic contributions to cardiovascular diseases.
Diet-Induced Methods: Using high-fat diets to study atherosclerosis and lipid metabolism.
Surgical Techniques: Replicating conditions like myocardial infarction (heart attack), hypertension, heart failure, or arrhythmias.

Collaborate with us to access advanced cardiovascular animal models and a dedicated team focused on advancing heart health and therapeutic development.

Wound Healing models

Wound healing models in biomedical research are essential for studying the complex tissue repair and regeneration process. These animal models mimic various aspects of wound healing observed in humans, allowing researchers to investigate factors influencing healing outcomes and test novel therapeutic interventions.

Commonly used models include:

Excisional Wounds in Rodents: Controlled wounds are created on the skin of mice or rats to monitor healing stages, from inflammation and proliferation to tissue remodeling.
Internal Organ Wounds: Models involving wounds on organs like the liver or intestines to study specific repair mechanisms.

Our Researchers assess wound healing by measuring parameters such as:

Wound Closure Rates: Tracking the speed of healing over time.
Tissue Regeneration: Evaluating the quality of new tissue formation.
Collagen Deposition: Analyzing the structural protein critical for wound strength.
Inflammatory Cell Infiltration: Monitoring immune responses at the wound site.

At PRISM CRO, our wound healing models offer valuable insights into the mechanisms of tissue repair and the effectiveness of new therapies, supporting advancements in regenerative medicine and wound care. Collaborate with us to access cutting-edge animal models and a dedicated team committed to improving wound healing outcomes.

Ischemic Stroke Model

The ischemic stroke model induced by the obstruction of the common carotid artery is a widely used approach in stroke research. This model closely mimics the clinical scenario of ischemic stroke, where a blockage in a major artery restricts blood flow to the brain, leading to ischemia and subsequent tissue damage.

In this model, we perform surgical interventions on animal subjects, typically rats, to permanently or temporarily obstruct the common carotid artery or its branches. This procedure results in reduced blood flow to brain regions supplied by the affected artery, creating ischemic conditions similar to those observed in human strokes. The extent and duration of ischemia can be precisely controlled and varied based on the experimental design. At PRISM CRO, our ischemic stroke model provides valuable insights into the mechanisms of stroke and the efficacy of potential treatments, supporting advancements in neuroprotective therapies and stroke recovery.

Collaborate with us to access state-of-the-art stroke animal models and a dedicated team focused on improving outcomes for stroke patients.